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A S Verkman Selected Research

Aquaporins (Water Channels)

1/2016Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1.
3/2015Aquaporin-1 water permeability as a novel determinant of axonal regeneration in dorsal root ganglion neurons.
2/2014Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia.
11/2013Biology of AQP4 and anti-AQP4 antibody: therapeutic implications for NMO.
6/2013Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase.
12/2012Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions.
12/2012Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly.
6/2012Aquaporin 4 and neuromyelitis optica.
3/2012Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
3/2012Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.
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A S Verkman Research Topics

Disease

40Neuromyelitis Optica (Devic's Disease)
11/2021 - 06/2009
38Cystic Fibrosis (Mucoviscidosis)
05/2016 - 03/2000
19Demyelinating Diseases (Demyelinating Disease)
11/2021 - 08/2009
18Neoplasms (Cancer)
01/2016 - 01/2003
18Diarrhea
02/2014 - 12/2003
17Brain Edema (Cerebral Edema)
03/2014 - 02/2000
15Inflammation (Inflammations)
11/2021 - 12/2002
11Glaucoma
01/2016 - 09/2001
8Edema (Dropsy)
01/2016 - 12/2000
8Polycystic Kidney Diseases (Polycystic Kidney Disease)
10/2015 - 05/2008
8Neuroinflammatory Diseases
04/2014 - 05/2011
8Nephrogenic Diabetes Insipidus
01/2012 - 04/2000
7Cholera
09/2012 - 12/2003
7Lung Diseases (Lung Disease)
08/2010 - 01/2003
6Obesity
01/2012 - 01/2005
5Inborn Genetic Diseases (Disease, Hereditary)
02/2012 - 11/2001
5Epilepsy (Aura)
01/2012 - 01/2005
5Carcinogenesis
06/2009 - 01/2008
5Water Intoxication
08/2008 - 02/2000
4Infections
07/2014 - 03/2008
4Autoimmune Diseases (Autoimmune Disease)
05/2014 - 08/2009
4Hypertension (High Blood Pressure)
01/2011 - 09/2001
3Dry Eye Syndromes (Dry Eye Syndrome)
01/2016 - 04/2005
3Pain (Aches)
03/2015 - 03/2006
3Brain Ischemia (Cerebral Ischemia)
06/2014 - 12/2004
3Neoplasm Metastasis (Metastasis)
03/2014 - 05/2008
3Cataract (Cataracts)
01/2012 - 09/2006
3Fibrosis (Cirrhosis)
10/2011 - 09/2004
3Cysts
08/2011 - 07/2008
3Hydrocephalus (Hydrocephaly)
01/2011 - 12/2006
3Wounds and Injuries (Trauma)
08/2009 - 10/2006
3Ischemia
03/2006 - 12/2004
2Multiple Sclerosis
03/2012 - 06/2009
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
05/2011 - 08/2009
2Seizures (Absence Seizure)
06/2009 - 01/2006
2Heart Failure
01/2009 - 09/2001
2Gliosis
05/2008 - 01/2008
2Polyuria
08/2006 - 10/2005
2Skin Diseases (Skin Disease)
06/2006 - 07/2005
2Acute Kidney Injury (Acute Renal Failure)
05/2006 - 12/2005
2Corneal Edema
03/2006 - 02/2003
2Pleural Effusion (Pleural Effusions)
12/2000 - 06/2000
1Constipation
05/2016

Drug/Important Bio-Agent (IBA)

49Aquaporins (Water Channels)IBA
01/2016 - 02/2000
31Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
10/2015 - 06/2001
29AutoantibodiesIBA
11/2014 - 06/2009
28Chloride Channels (Chloride Channel)IBA
05/2016 - 01/2003
27Immunoglobulin G (IgG)IBA
11/2021 - 08/2005
18Complement System Proteins (Complement)IBA
11/2021 - 02/2010
14Pharmaceutical PreparationsIBA
01/2016 - 11/2001
8Proteins (Proteins, Gene)FDA Link
03/2014 - 06/2001
8Glycerol (Glycerine)FDA LinkGeneric
06/2009 - 04/2005
7Enterotoxins (Enterotoxin)IBA
02/2014 - 12/2003
5DiureticsIBA
09/2014 - 01/2005
5Cholera ToxinIBA
07/2014 - 08/2004
5ChloridesIBA
08/2010 - 01/2006
5cystic fibrosis transmembrane conductance regulator delta F508IBA
01/2010 - 09/2004
4Protein Isoforms (Isoforms)IBA
12/2012 - 12/2009
4AquaglyceroporinsIBA
06/2009 - 06/2006
4Aquaporin 2IBA
02/2009 - 01/2001
4Adenosine Triphosphate (ATP)IBA
09/2008 - 01/2008
3AntibodiesIBA
11/2021 - 06/2012
3Phenobarbital (Luminal)FDA Link
05/2016 - 12/2013
3AnionsIBA
01/2016 - 03/2000
3Phenylalanine (L-Phenylalanine)FDA Link
12/2014 - 09/2005
3SaltsIBA
09/2014 - 02/2001
3Cyclic NucleotidesIBA
02/2014 - 01/2009
3Immunoglobulins (Immunoglobulin)IBA
09/2013 - 02/2010
3CytokinesIBA
11/2012 - 10/2005
3Aquaporin 4IBA
06/2012 - 04/2005
3Peptides (Polypeptides)IBA
05/2011 - 09/2001
2Neuroprotective AgentsIBA
06/2014 - 02/2014
2Acetaminophen (Paracetamol)FDA LinkGeneric
03/2014 - 09/2006
2Aquaporin 1IBA
03/2014 - 01/2011
2Biological ProductsIBA
02/2014 - 12/2013
2Peptide Hydrolases (Proteases)FDA Link
06/2013 - 03/2012
2Monoclonal AntibodiesIBA
06/2013 - 03/2012
2Myelin-Oligodendrocyte GlycoproteinIBA
05/2011 - 08/2009
2KaolinIBA
01/2011 - 12/2006
2Mutant Proteins (Protein, Mutant)IBA
04/2010 - 01/2010
2fluorexon (calcein)IBA
08/2009 - 08/2008
2glycine hydrazideIBA
07/2008 - 01/2006
2IodidesIBA
03/2008 - 09/2004
2fluorescein isothiocyanate dextranIBA
01/2008 - 03/2005
2Dextrans (Dextran)FDA Link
01/2008 - 11/2007
2Retinaldehyde (Retinal)IBA
03/2006 - 12/2004
2AntidiarrhealsIBA
01/2006 - 08/2004
2Triglycerides (Triacylglycerol)IBA
04/2005 - 01/2001
2AcidsIBA
11/2001 - 06/2000
2ThioureaIBA
12/2000 - 06/2000
1Intravenous Immunoglobulins (IVIG)FDA Link
01/2018
1Loperamide (Imodium)FDA LinkGeneric
05/2016
1Clobetasol (Clobetasol Propionate)FDA LinkGeneric
01/2016
1Interleukin-13IBA
01/2016
1anti-aquaporin 4 autoantibodyIBA
01/2016
1Carboxylic AcidsIBA
10/2015

Therapy/Procedure

44Therapeutics
10/2015 - 11/2001
3Drug Therapy (Chemotherapy)
11/2011 - 05/2008
1Topical Administration
01/2016
1Combination Drug Therapy (Combination Chemotherapy)
10/2015